African American respondents had a significantly higher mean distrust index score than white respondents (3.1 vs 1.8, P<.01). Our main outcome measure was a 7-item index of distrust.Īfrican American respondents were more likely than white respondents not to trust that their physicians would fully explain research participation (41.7% vs 23.4%, P<.01) and to state that they believed their physicians exposed them to unnecessary risks (45.5% vs 34.8%, P<.01). We analyzed data from 527 African American and 382 white respondents of a national telephone survey on participation in clinical research. To examine possible differences in distrust by race and to determine to what extent other sociodemographic factors explain any racial differences in distrust.
Investigators have voiced concerns that distrust of research and the medical community impedes successful recruitment of African Americans into clinical research.
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